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127 The 2-substituted benzofuran compound is synthesized by heterocyclic response of o-iodophenol having an acetylene substrate that contains a terminal acetylene group. This artificial route has focused on the use of palladium catalysts to type carbon–carbon bonds and carbon-heteroatom bonds. This route is also a flexible and straightforward system to the synthesis of benzofuran compounds.128–130
concerning the synthesis of benzofuran derivatives. Yu et al.108 documented the catalyst-free synthesis of benzofuran
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Plan 5 The benzofuran ring was created by a coupling-cyclization response of o-iodophenol with a terminal alkyne.